Professor Zhou (周强辉) (PI)

 

Qianghui Zhou, Ph.D., Professor, “National Science Fund for Distinguished Young Scholars”

College of Chemistry and Molecular Sciences

Institute for Advanced Studies

Wuhan University, Wuhan, China, 430072

Email: qhzhou@whu.edu.cn

Tel: 86-027-68755487

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      

 Biographical Sketch

Qianghui was born and raised in a small village of Xiangtan, Hunan, China (The hometown of Chairman Mao). He began undergraduate studies at Peking University in 2001, and obtained his B.S. degree in chemistry in 2005. While at Peking University, Qianghui conducted undergraduate research in the laboratory of Prof. Weihong Li and Jinguang Wu, focusing on preparation of novel coordinated inorganic polymers. In the fall of 2005, he began doctoral studies at Shanghai Institute of Organic Chemistry (SIOC) under the direction of Prof. Dawei Ma. During this period, Qianghui completed 1) the first enantioselective synthesis of (-)-englerin A, an anti-renal cancer sesquiterpene; 2) an efficient formal synthesis of cyclopeptide RP-66453. Upon completion of his graduate studies in 2010 and subsequent one-year employment as a research associate at SIOC, Qianghui was awarded a post-doctoral fellowship from SIOC and Zhejiang Medicine Co., and moved to The Scripps Research Institute (TSRI) to pursue post-doctoral studies in the laboratory of Prof. Phil S. Baran. The research focus was on 1) the semi-synthesis of highly oxidated steroids; 2) sulfinate salts involved C-H bond functionalization of heterocycles. In June 2015, Qianghui accepted an appointment at Wuhan University, where he is a professor in the College of Chemistry and Molecular Sciences and the Institute for Advanced Studies.

 

Research Interests

1.Novel synthetic methodology and tactic development (target oriented)

2.Efficient and practical (scalable) synthesis of highly valued natural products and derivatives

3.Process chemistry development for important medicines

 

Professional Experience
2015.8–Present  Joint Professor

Institute for Advanced Studies, Wuhan University, Wuhan, China

2015.6–Present  Professor

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China

 

Education        

2011.8–2015.5  Postdoctoral Fellow

The Scripps Research Institute, Chemistry Department, La Jolla, CA, USA

Advisor: Prof. Phil S. Baran

 

2010.7–2011.7  Research Associate

State Key Laboratory of Bioorganic and Natural Products Chemistry,

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

Advisor: Prof. Dawei Ma

 

2005.9–2010.7  Ph. D. in Organic Chemisrty

State Key Laboratory of Bioorganic and Natural Products Chemistry,

Shanghai Institute of Organic chemistry, CAS, Shanghai, China

Advisor: Prof. Dawei Ma

Project: Total Synthesis of Biological Active Natural Products, Including RP-66453, (-)-Englerin A and (-)-Nakadomarin A

 

2001.9–2005.7  B. S. in Chemistry

College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Advisor: Prof. Weihong Li and Prof. Jin-Guang Wu

Project: Synthesis of Novel Coordination Polymers

 

Honors and Awards            

2017  Thieme Chemistry Journal Awards

2015  National Thousand Talents Award

2013  Reaxys Travel Award-ISHC24

2011−2013  SIOC Postdoctoral Fellowship, SIOC

2011  Reaxys PhD Prize, Runners-up, Elsevier

2010  Merit Student Honor, Chinese Academy of Science

2010  GlaxoSmithKline Scholarship, SIOC

2003−2004  Merit Student Honor, Peking University

2003−2004  Wu–Si Award for Outstanding Senior Students, Peking University

2002−2003  Canon Scholarship, Peking University

2001−2002  Guanghua Scholarship, Peking University

2001  President Award for Outstanding Freshmen, Peking University

2001  1st Class Award, the 14th National Chemistry Olympiad, Changsha, Hunan, China

 

 

Publications

1. Redox-Neutral Ortho-C‒H Amination of Pinacol Arylborates via Palladium(II)/Norbornene Catalysis for Anilines Synthesis. Shuqing Chen†, Peng Wang†, Hong-Gang Cheng, Chihui Yang and Qianghui Zhou*. Chem. Sci. 2019.

2. A Biocatalytic Hydroxylation Enabled Unified Approach to C19-H hydroxylated Steroids. Junlin Wang§, Yanan Zhang§, Huanhuan Liu, Yong Shang, Linjun Zhou, Penglin Wei, Wen-Bing Yin, Zixin Deng, Xudong Qu*, Qianghui Zhou*. Nature Commun. 2019.

3. The Pd(II)‐Initiated Catellani‐type Reactions. Hong-Gang Cheng, Shuqing Chen, Ruiming Chen, and Qianghui Zhou*, Angew. Chem. Int.Ed. 2019, 58, 5832–5844.

4. Bridgehead-Modified NBEs: A Solution to ortho-Constraint in Catellani-type Reactions. Hong-Gang Cheng and Qianghui Zhou*, Chem , 2018, 4, 1775–1777. (Preview)

5. Modular One‐Step Three‐Component Synthesis of Tetrahydroisoquinolines via a Catellani Strategy. Guangyin Qian, Miao Bai, Shijun Gao, Han Chen, Siwei Zhou, Hong-Gang Cheng*, Wei Yan and Qianghui Zhou*. Angew. Chem. Int. Ed. 2018, 57, 10980 –10984.

6. The Discovery of A Pd(II)-Initiated Borono-Catellani Reaction. Shuqing Chen†, Ze-Shui Liu†, Tao Yang, Yu Hua, Zhiyu Zhou, Hong-Gang Cheng and Qianghui Zhou*. Angew. Chem. Int. Ed. 2018, 57, 7161 –7165.

7. A Palladium/Norbornene Cooperative Catalysis to Access Tetrahdronaphthalenes and Indanes with a Quaternary Center. Zeshui Liu‡, Guangyin Qian‡, Qianwen Gao, Peng Wang, Hong-Gang Cheng, Qiang Wei, Qi Liu, and Qianghui Zhou*. ACS Catalysis, 2018, 8, 4783–4788.

8. Epoxides as Alkylating Reagents for the Catellani Reaction. Hong-Gang Cheng, Chenggui Wu, Han Chen†, Ruiming Chen†, Guangyin Qian, Zhi Geng, Qiang Wei,Yuanyuan Xia, Jingyang Zhang, Yuming Zhang and Qianghui Zhou* . Angew. Chem. Int. Ed, 2018, 57, 3444-3448. (selected as cover)

 

Patents

  1. D. Ma, S. Zhu, S. Yu, Y. Wang, Q. Zhou,  “Intermediate compounds of tamiflu, methods of preparation and uses thereof”, WO/2011/076086
  2. 周强辉、吴承贵、程鸿刚，“ 一种合成2, 3-二氢苯并呋喃类化合物的方法”，申请号：2018102990428.
  3. 周强辉、刘泽水、钱光印， “一种具有苄位季碳中心的苯并环衍生物及氢溴酸依他佐辛的制备方法”，申请号：2018102990220.
  4. 周强辉、钱光印、白淼，“一种1,2,3,4-四氢异喹啉衍生物的制备方法”，申请号：201810659587.5
  5. 周强辉、翟旭东、王军林、张亚楠，“19羟基克托多松衍生物及19-羟基雄烯二酮的制备方法”，申请号：201910517841.2
  6. 瞿旭东，周强辉，张亚楠，王军林，“一种用于系列甾类化合物19位羟化的生物转化方法”，申请号：201910152033.0

 

Presentation                    

1.ISHC24 Congress, Shanghai, China, September. 8-13, 2013 Oral presentation: Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin

2.ISHC24 Congress, Shanghai, China, September. 8-13, 2013 Poster: Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

3.The 2010 11th Tetrahedron Symposium, Beijing, China, June. 22-25, 2010 Poster: Total Synthesis of (-)-Englerin A

4.The 2nd ISOSDD, Nanjing, China, Oct. 14-17, 2010 (Poster Awarded) Poster: Asymmetric, Protecting Group-Free Total Synthesis of (-)-Englerin A